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  • Can menopause drugs lead to an increase in blood clot? Can menopause drugs lead to an increase in blood clot?


    Many women who are about to reach the menopause or have reached the menopause stage tend to use the estrogen therapy drug. This drug is used in the treatment of menopause. And this therapy is said to increase the risk of having blood clots. read more


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Health Hazards

Heart Disease

Cancer

  • Validity and usefulness of a single-item measure of patient-reported bother from side effects of cancer therapy.

    Validity and usefulness of a single-item measure of patient-reported bother from side effects of cancer therapy.

    Cancer. 2017 Nov 13;:

    Authors: Pearman TP, Beaumont JL, Mroczek D, O'Connor M, Cella D

    Abstract
    BACKGROUND: The improving efficacy of cancer treatment has resulted in an increasing array of treatment-related symptoms and associated burdens imposed on individuals undergoing aggressive treatment of their disease. Often, clinical trials compare therapies that have different types, and severities, of adverse effects. Whether rated by clinicians or patients themselves, it can be difficult to know which side effect profile is more disruptive or bothersome to patients. A simple summary index of bother can help to adjudicate the variability in adverse effects across treatments being compared with each other.
    METHODS: Across 4 studies, a total of 5765 patients enrolled in cooperative group studies and industry-sponsored clinical trials were the subjects of the current study. Patients were diagnosed with a range of primary cancer sites, including bladder, brain, breast, colon/rectum, head/neck, hepatobiliary, kidney, lung, ovary, pancreas, and prostate as well as leukemia and lymphoma. All patients were administered the Functional Assessment of Cancer Therapy-General version (FACT-G). The single item "I am bothered by side effects of treatment" (GP5), rated on a 5-point Likert scale, is part of the FACT-G. To determine its validity as a useful summary measure from the patient perspective, it was correlated with individual and aggregated clinician-rated adverse events and patient reports of their general ability to enjoy life.
    RESULTS: Analyses of pharmaceutical trials demonstrated that mean GP5 scores ("I am bothered by side effects of treatment") significantly differed by maximum adverse event grade (P<.001) in all trials, with a clear trend toward increasing GP5 scores with level of increasing adverse event grade. Effect sizes ranged from 0.13 to 0.46. Analyses of cooperative group trials demonstrated a significant correlation between GP5 and item GF3 ("I am able to enjoy life") in the predicted direction.
    CONCLUSIONS: The single FACT-G item "I am bothered by side effects of treatment" is significantly associated with clinician-reported adverse events and with patients' ability to enjoy their lives. It has promise as an overall summary measure of the burden of a given set of treatment toxicities compared with another. Future research can identify the contribution of individual side effects compared with one another in terms of how each may contribute to overall bother. Cancer 2017. © 2017 American Cancer Society.

    PMID: 29131323 [PubMed - as supplied by publisher]


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Stroke

  • Is migraine and stroke connected? Is migraine and stroke connected?


    Is migraine and stroke connected? Don’t know for sure? Try out this exercise- list down the symptoms of a migraine on sheet of the paper and list down the symptoms of a stroke on the other sheet of paper. What do you see? Right, the symptoms read more


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COPD

  • COPD (Chronic Obstructive Pulmonary Disease ) COPD (Chronic Obstructive Pulmonary Disease )


    COPD stands for Chronic Obstructive Pulmonary Disease which is responsible for obstructing the lungs and airways that keep your body and life active. As the name indicates, this group of disease is mainly caused due to smoking, allergies and read more


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Alzheimer's Disease

  • Alzheimers disease Alzheimers disease


    As compared to men, women have got increased frequency of acquiring Alzheimer’s disease above age of 65 and the researchers have further claimed that 17% women are facing memory loss and dementia problems in America in contrast of 9% men. read more


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Diabetes

  • Treatments & causes of diabetes Treatments & causes of diabetes


    In case of women, diabetes can be very hard and may affect both the pregnant ladies and children and thus it becomes very important to know the causes of diabetes, right from the beginning. Diabetes is supposed to have some sort of difficulties read more


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Influenza and Pneumonia

  • Protection against Influenza and Pneumonia Protection against Influenza and Pneumonia


    In the death list for America, influenza and pneumonia when combined, act as the eighth leading cause of death in women. Both of these diseases can be counted under the category of respiratory illness which accounts for not less than 3% women read more


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Kidney Disease