Palbociclib in Hormone-Receptor-Positive Advanced Breast Cancer.

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Palbociclib in Hormone-Receptor-Positive Advanced Breast Cancer.

N Engl J Med. 2015 Oct 22;373(17):1672-1673

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Abstract
To the Editor: In the PALOMA3 study, Turner et al. (July 16 issue)(1) report that the addition of palbociclib to fulvestrant improved progression-free survival as compared with fulvestrant alone in patients with advanced breast cancer, with similar discontinuation rates because of adverse effects (2.6% and 1.7%, respectively). However, molecularly targeted therapies have moderate toxic effects that may become unacceptable over the long term and result in a deterioration in the quality of life, as shown in a previous report.(2),(3) The PALOMA1 study, a previous phase 2 trial of palbociclib with a median follow-up of approximately 30 months, showed that . . .

PMID: 26488700 [PubMed – as supplied by publisher]